Thioridazine Is an Efflux Pump Inhibitor in Mycobacterium avium Complex but of Limited Clinical Relevance
نویسندگان
چکیده
منابع مشابه
Thioridazine and chlorpromazine inhibition of ethidium bromide efflux in Mycobacterium avium and Mycobacterium smegmatis.
OBJECTIVES Therapy of AIDS patients infected with Mycobacterium avium is problematic due to its intrinsic resistance to antibiotics. We have characterized the efflux pump activity of M. avium wild-type strain through an automated fluorometric method and correlated it with intrinsic resistance to antibiotics. METHODS M. avium ATCC 25291(T) and Mycobacterium smegmatis mc(2)155 were evaluated fo...
متن کاملThioridazine as Chemotherapy for Mycobacterium avium Complex Diseases
Mycobacterium avium-intracellulare complex (MAC) causes an intractable intracellular infection that presents as chronic pulmonary disease. Currently, therapy consists of ethambutol and macrolides and takes several years to complete. The neuroleptic phenothiazine thioridazine kills mycobacteria by inhibiting the electron transport chain. In several experiments with bacterial populations of up to...
متن کاملFarnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis.
The active multidrug efflux pump (EP) has been described as one of the mechanisms involved in the natural drug resistance of bacteria, such as mycobacteria. As a result, the development of efflux pumps inhibitors (EPIs) is an important topic. In this study, a checkerboard synergy assay indicated that farnesol both decreased the minimum inhibitory concentration (MIC) of ethidium bromide (EtBr) 8...
متن کاملMycobacterium Avium Complex
These two species are difficult to differentiate and therefore they are also referred to collectively as Mycobacterium avium-intracellulare (MAI) . Although it might more logically be termed the Mycobacterium avium-intracellulare complex such nomenclature has not been adopted. They are both opportunistic pathogens that affect the immunocompromised, particularly HIV-positive individuals. They ca...
متن کاملMycobacterium Avium Complex
These two species are difficult to differentiate and therefore they are also referred to collectively as Mycobacterium avium-intracellulare (MAI) . Although it might more logically be termed the Mycobacterium aviumintracellulare complex such nomenclature has not been adopted. They are both opportunistic pathogens that affect the immunocompromised, particularly HIV-positive individuals. They can...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2020
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00181-20